6/30/2017 12:00:00 AM
This alert highlights the drug-drug interaction between an anticoagulant, warfarin, and an anti-fungal, miconazole. The interaction between warfarin and miconazole increases the effect of warfarin, so that the blood-thinning ability (INR) is increased, which in turn can cause severe bleeding. The risk of interaction also applies to miconazole oral gel, as a large proportion of this is absorbed systemically. Other antifungals such as fluconazole and voriconazole have the same effect on warfarin. A recommendation to prevent adverse events when it is necessary to use warfarin and an antifungal concomitantly is provided.
miconazole oral gel (Brentan®),
antithrombotic agents (anticoagulants),
Be aware of the interaction between warfarin and miconazole oral gel