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Louise Simard was elected to the Legislative Assembly of Saskatchewan in 1986 and again in 1991, at which time she became the Minister of Health and Minister Responsible for the Status of Women. She has held numerous other ministerial portfolios, including being a member of Treasury Board, Minister Responsible for the Saskatchewan Cancer Foundation, the Health Services Utilization and Research Commission and the Saskatchewan Women's Advisory Council.

Under Louise's leadership, Saskatchewan led a comprehensive, province-wide health reform to reorganize and integrate health services throughout the province, in which 440 health boards were dissolved and moved into regions. She is an advocate for health promotion, disease prevention, population health goals and primary healthcare. The process also included unprecedented fiscal restraint. Saskatchewan was seen as a leader in the reform process in Canada in the early 1990s. Louise is a former CEO of the Saskatchewan Association of Health Organizations and of the Health Employers Association of British Columbia. Louise was the first non-physician appointed president of the Medical Council of Canada. She has served on many boards and agencies, including the Canadian Nurses Association, Victorian Order of Nurses (VON), Saskatchewan Population Health Evaluation and Research Unit, Saskatchewan Lung Association, Saskatchewan Power Corporation, SaskTel, Health Benefit Trusts and Pension Boards.

Louise presently is a Professional Affiliate of the School of Public Health, University of Saskatchewan, and she sits as a member of the Council of the Royal College of Physicians and Surgeons of Canada. She does work for the Medical Council of Canada, continues with speaking engagements and manages her farm near Regina.